Endocrine Abstracts

Objective: Anorexia nervosa (AN) is often associated with severe mineral bone loss and increased risk of fractures. The objective of this study was to assess the bone mineral density (BMD) in patients with AN and its relationship with different anthropometrics, clinical and hormonal parameters.Patients and methods: We evaluated 47 women with AN according to criteria of DSM-IV. The anthropometrics variables measured were: weight (kg) height (m), BMI (kg/m...

Introduction: Postoperative hypocalcemia is among the most frequent morbidities after total thyroidectomy. Although most postoperative hypocalcemia is temporary, it causes prolonged hospitalization and a decrease in quality of life. For all this, early diagnosis is essential to start treatment as soon as possible. In this study, we determined whether early serum calcium levels can predict the development hipoparathyroidism.Methods: A total of 122 patient...

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

Introduction: Acute hyperlipidemic pancreatitis is a rare clinical entity that usually affects patients with previous lipid alterations (triglyceride concentration >500 mg/dl) associated with triggering secondary factors, such as poorly controlled diabetes mellitus (DM).Clinical Case: We present the case of a 60-year-old man who came to the Emergency Department with a picture of acute abdominal pain secondary to acute pancreatitis in which a small hy...

Objective: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) it’s a histological entity that describes a low-aggressive neoplasm previously classified as encapsulated follicular variant of papillary thyroid carcinoma and well differentiated tumour of uncertain malignant potential. The preoperative diagnosis it’s difficult, and if we suspect it hemithyroidectomy or lobectomy it’s the therapeutic management of choice. Therefore,...

Fatty liver (steatosis) can progress to non-alcoholic fatty liver disease, increasing the risk of diabetes and cardiovascular disease. Growth hormone (GH) deficiency is associated with steatosis, while raising GH reduces steatosis. To date it remains to be determined how GH mediates this hepato-protective effect. To investigate the hepatocyte-specific actions of GH, a mouse model of adult-onset hepatocyte-specific GH receptor knockdown (aHepGHRkd) was generated by treating adu...

Background: Hyperandrogenism is infrequent in menopause, being the most common cause benign pathologies. However, it can also be produced by an ovarian or adrenal tumour. Correct diagnosis and location can be challenging because small lesions may not be visible with modern imaging studies. We report a case of ovarian stromal hyperplasia where selective venous catheterization and hormonal sampling were performed to find the origin of excessive androgen production.<p class="...

Aims: To evaluate real-world efficacy of closed-loop systems (CLS) (MinimedTM 780G, DBLG1 -Diabeloop- and Control-IQTM Tandem) as well as to assess those predictive factors related with the achievement of near-normal glycemic control.Methods: A prospective, longitudinal, and observational study was performed. It included T1D adults who initiated CLS between April and December 2021 in our hospital and provided data for &gE;3 months (...

Liver autophagy, as assessed by accumulation of LC3-II and p62 proteins, is positively correlated with the severity of nonalcoholic steatohepatitis (NASH) in humans. Since growth hormone (GH) is negatively associated with liver steatosis and NASH development, and our laboratory has reported that steatosis and NASH develops in a mouse model of adult-onset, hepatocyte-specific GH-Receptor knockdown (aHepGHRkd), we sought to determine if GH directly regulates the hepatocyte autop...

Introduction: Graves’ ophthalmopathy (GO) is an orbital autoimmune disorder closely linked to thyroid autoimmunity, mainly Graves’ disease. After an initial progressive inflammatory period (active phase), GO stabilizes and eventually subsides (inactive phase). Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient’s quality of life. Patients with active, mild disease generally benefit from local therapies ...